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John Kucewicz

Senior Engineer

Email

kucewicz@apl.washington.edu

Phone

206-221-3283

Publications

2000-present and while at APL-UW

Rapid ultrasonic stimulation of inflamed tissue with diagnostic intent

McClintic, A.M., T.C. Dickey, M. Gofeld, P.R. Illian, M. Kliot, J.C. Kucewicz, J.D. Loeser, P.G. Richebe, and P.D. Mourad, "Rapid ultrasonic stimulation of inflamed tissue with diagnostic intent," J. Acoust. Soc. Am., 134, 1521-1529, doi:10.1121/1.4812872, 2013.

More Info

1 Aug 2013

Previous studies have observed that individual pulses of intense focused ultrasound (iFU) applied to inflamed and normal tissue can generate sensations, where inflamed tissue responds at a lower intensity than normal tissue. It was hypothesized that successively applied iFU pulses will generate sensation in inflamed tissue at a lower intensity and dose than application of a single iFU pulse. This hypothesis was tested using an animal model of chronic inflammatory pain, created by injecting an irritant into the rat hind paw. Ultrasound pulses were applied in rapid succession or individually to rats' rear paws beginning at low peak intensities and progressing to higher peak intensities, until the rats withdrew their paws immediately after iFU application. Focused ultrasound protocols consisting of successively and rapidly applied pulses elicited inflamed paw withdrawal at lower intensity and estimated tissue displacement values than single pulse protocols. However, both successively applied pulses and single pulses produced comparable threshold acoustic dose values and estimates of temperature increases. This raises the possibility that temperature increase contributed to paw withdrawal after rapid iFU stimulation. While iFU-induction of temporal summation may also play a role, electrophysiological studies are necessary to tease out these potential contributors to iFU stimulation.

Characterizing an agar/gelatin phantom for image guided dosing and feeback control of high-intensity focused ultrasound

Dunmire, B., J.C. Kucewicz, S.B. Mitchell, L.A. Crum, and K.M Sekins, "Characterizing an agar/gelatin phantom for image guided dosing and feeback control of high-intensity focused ultrasound," Ultrasound Med. Biol., 39, 300-311, 2013.

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1 Feb 2013

The temperature dependence of an agar/gelatin phantom was evaluated. The purpose was to predict the material property response to high-intensity focused ultrasound (HIFU) for developing ultrasound guided dosing and targeting feedback. Changes in attenuation, sound speed, shear modulus and thermal properties with temperature were examined from 20°C to 70°C for 3 weeks post-manufacture. The attenuation decreased with temperature by a power factor of 0.15. Thermal conductivity, diffusivity and specific heat all increased linearly with temperature for a total change of approximately 16%, 10% and 6%, respectively. Sound speed had a parabolic dependence on temperature similar to that of water. Initially, the shear modulus irreversibly declined with even a slight increase in temperature. Over time, the gel maintained its room temperature shear modulus with moderate heating. A stable phantom was achieved within 2 weeks post-manufacture that possessed quasi-reversible material properties up to nearly 55°C.

Autoregressive ultrasound imaging method to enhance kidney stone twinkling and suppress blood flow

Kucewicz, J.C., B.W. Cunitz, B. Dunmire, M.R. Bailey, and L.A. Crum, "Autoregressive ultrasound imaging method to enhance kidney stone twinkling and suppress blood flow," J. Acoust. Soc. Am., 129, 2376, doi:10.1121/1.3587699, 2011.

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1 Apr 2011

"Twinkling" is a widely reported ultrasound artifact whereby kidney stones and other similar calcified, strongly reflective objects appear as turbulent, flowing blood in color and power Doppler. The twinkling artifact has been shown to improve kidney stone detection over B-mode imaging alone, but its use has several limitations. Principally, twinkling can be confused with blood flow, potentially leading to an incorrect diagnosis. Here a new method is reported for explicitly suppressing the display of color from blood flow to enhance and/or isolate the twinkle signal. The method applies an autoregressive model to standard Doppler pulses in order to differentiate tissue, blood flow, and twinkling. The algorithm was implemented on a software-based, open architecture ultrasound system and tested by a sonographer on phantoms and on stones implanted in a live porcine kidney. Stones of 3-10 mm were detected reproducibly while suppressing blood flow in the image. In conclusion, a new algorithm designed to specifically detect stones has been tested and has potential clinical utility especially as efforts are made to reduce radiation exposure on diagnosis and monitoring.

More Publications

Inventions

System and Methods for Tracking Finger and Hand Movement Using Ultrasound

Record of Invention Number: 47931

John Kucewicz, Brian MacConaghy, Caren Marzban

Disclosure

10 Jan 2017

Supplemental Know How for Pushing, Imaging, and Breaking Kidney Stones

Record of Invention Number: 47878

Mike Bailey, Larry Crum, Bryan Cunitz, Barbrina Dunmire, Vera Khokhlova, Wayne Kreider, John Kucewicz, Dan Leotta

Disclosure

9 Nov 2016

Ultrasound based method and apparatus for stone detection and to facilitate clearance thereof

Patent Number: 9,204,859

Mike Bailey, Bryan Cunitz, Barbrina Dunmire, John Kucewicz, Oleg Sapozhnikov

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Patent

8 Dec 2015

Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.

More Inventions

Acoustics Air-Sea Interaction & Remote Sensing Center for Environmental & Information Systems Center for Industrial & Medical Ultrasound Electronic & Photonic Systems Ocean Engineering Ocean Physics Polar Science Center
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